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A collision tumor: Pituitary apoplexy caused by lung cancer metastasis
J Korean Skull Base Soc 2023;18(2):156-163
Published online October 31, 2023
© 2023 Korean Skull Base Society.

Jaemin Yu1, Se Hoon Kim2,3, Eui Hyun Kim1,3,4

1Department of Neurosurgery, Yonsei University College of Medicine, Seoul, Korea
2Department of Pathology, Yonsei University College of Medicine, Seoul, Korea
3Pituitary Tumor Center, Severance Hospital, Seoul, Korea
4Endoscopic Skull Base Center, Severance Hospital, Seoul, Korea
Correspondence to: Eui Hyun Kim
Received June 21, 2023; Revised July 27, 2023; Accepted July 27, 2023.
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
A collision tumor refers to a rare phenomenon where two distinct neoplasms coexist occupying the same anatomical location. While metastatic brain tumors and pituitary adenoma are two of the most common intracranial tumors, the collision of the two tumors are extremely rare. We report a 76-year-old female patient with progressive visual field defect. She had a history of a stable pituitary adenoma and was recently diagnosed with lung adenocarcinoma with no known distant metastasis but with malignant pleural effusion. Her brain magnetic resonance imaging suggested a possible pituitary apoplexy with profound optic nerve compression. The patient underwent transsphenoidal surgery for tumor removal and the presence of metastatic cancer was confirmed by histopathological examination.
Keywords : Metastasis, Lung cancer, Pituitary adenoma, Apoplexy

October 2023, 18 (2)
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