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Clinical efficacy of hypofractionated shaped-beam stereotactic radiosurgery in patients with skull base meningioma: Single center experience
J Korean Skull Base Soc 2022;17(1):5-10
Published online May 31, 2022
© 2022 Korean Skull Base Society.

Gyeong-Gyu Park1, Hyuk-Jin Oh1, Jae-Min Ahn1, Jae-Sang Oh1, Chul-Kee Min2

1Department of Neurosurgery, Soonchunhyang University Cheonan Hospital, Cheonan, Korea
2Department of Radiation Oncology, Soonchunhyang University Cheonan Hospital, Cheonan, Korea
Correspondence to: Hyuk-Jin Oh
주소 : Department of Neurosurgery, Soonchunhyang University Cheonan Hospital, 31 Suncheonhyang 6-gil, Dongnam-gu, Cheonan 31151, Korea
Tel : +82-41-570-3647
Fax : +82-41-572-9297
E-mail :
Received November 13, 2021; Revised March 3, 2022; Accepted March 23, 2022.
Background : Various modalities of stereotactic radiosurgery (SRS) have been proven to be effective and safe in the treatment of intracranial meningiomas. Depending on the characteristics of each modality, various results can be obtained. To analyze the therapeutic effect of hypofractionated SRS (hSRS) on skull base meningioma, we retrospectively reviewed the results of clinical and follow-up image studies.
Materials and Methods : Between January 2011 and December 2020, thirty-two patients (median age, 58 years; 5 males and 27 females) had been treated with hSRS using the Novalis Tx system for skull base meningiomas (mean volume, 7.86 cm3). Tumor was located in most frequently cavernous sinus (n = 7, 21.9%), cerebellopontine angle (n = 7, 21.9%), clinoidal (n = 6, 18.8%) locations. Thirteen patients had previously undergone surgical treatment including radiosurgery. The median cumulative dose was 25 Gy (range, 21.0-27.5 Gy) in five fractions (range, 3-5 fractions).
Results : During a median follow-up of 50 months (range, 13-98 months) hSRS achieves 100% tumor control rate in all patients without tumor progression. As a result of volumetric analysis using magnetic resonance imaging showed partial response (volume decrease > 20%) in 26 patients (81.3%), stable in 4 patients (12.5%). The tumor volume decreased by an average of 55.5% when compared with the beginning.
Conclusions : This study showed that hSRS is an effective and safe treatment modality with a high tumor control rate and functional outcomes for skull base meningioma.
Keywords : Meningioma, Radiosurgery, Skull base neoplasms

May 2023, 18 (1)
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